Dissecting Herpes Simplex Virus 1-Induced Host Shutoff at the RNA Level

Herpes simplex virus 1 (HSV-1) induces a profound host shutoff during lytic infection. The virion host shutoff (vhs) protein plays a key role in this process by efficiently cleaving host and viral mRNAs. Furthermore, the onset of viral DNA replication is accompanied by a rapid decline in host transc...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Friedel, Caroline C., Whisnant, Adam W., Djakovic, Lara, Rutkowski, Andrzej J., Friedl, Marie-Sophie, Kluge, Michael, Williamson, James C., Sai, Somesh, Vidal, Ramon Oliveira, Sauer, Sascha, Hennig, Thomas, Grothey, Arnhild, Milić, Andrea, Prusty, Bhupesh K., Lehner, Paul J., Matheson, Nicholas J., Erhard, Florian, Dölken, Lars
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2021
Assuntos:
Cellular Response to Infection
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925104/
https://ncbi.nlm.nih.gov/pubmed/33148793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01399-20
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