Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27

Infection by viruses, including herpes simplex virus-1 (HSV-1), and cellular stresses cause widespread disruption of transcription termination (DoTT) of RNA polymerase II (RNAPII) in host genes. However, the underlying mechanisms remain unclear. Here, we demonstrate that the HSV-1 immediate early pr...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Wang, Xiuye, Hennig, Thomas, Whisnant, Adam W., Erhard, Florian, Prusty, Bhupesh K., Friedel, Caroline C., Forouzmand, Elmira, Hu, William, Erber, Luke, Chen, Yue, Sandri-Goldin, Rozanne M., Dölken, Lars, Shi, Yongsheng
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962326/
https://ncbi.nlm.nih.gov/pubmed/31941886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14109-x
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