TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption

Toll-like receptor 7 (TLR7) agonist and PGT121 (broadly neutralizing antibody, bnAb) administration previously delayed viral rebound and induced SHIV remission. We evaluated the impact of GS-986 (TLR7 agonist) and dual bnAbs on viral rebound after antiretroviral therapy (ART) interruption. Rhesus ma...

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Bibliografski detalji
Izdano u:PLoS Pathog
Glavni autori: Hsu, Denise C., Schuetz, Alexandra, Imerbsin, Rawiwan, Silsorn, Decha, Pegu, Amarendra, Inthawong, Dutsadee, Sopanaporn, Jumpol, Visudhiphan, Pornsuk, Chuenarom, Weerawan, Keawboon, Boot, Shi, Wei, Robb, Merlin L., Mascola, John R., Geleziunas, Romas, Koup, Richard A., Barouch, Dan H., Michael, Nelson L., Vasan, Sandhya
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2021
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7924766/
https://ncbi.nlm.nih.gov/pubmed/33600506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009339
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