TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption

Toll-like receptor 7 (TLR7) agonist and PGT121 (broadly neutralizing antibody, bnAb) administration previously delayed viral rebound and induced SHIV remission. We evaluated the impact of GS-986 (TLR7 agonist) and dual bnAbs on viral rebound after antiretroviral therapy (ART) interruption. Rhesus ma...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Hsu, Denise C., Schuetz, Alexandra, Imerbsin, Rawiwan, Silsorn, Decha, Pegu, Amarendra, Inthawong, Dutsadee, Sopanaporn, Jumpol, Visudhiphan, Pornsuk, Chuenarom, Weerawan, Keawboon, Boot, Shi, Wei, Robb, Merlin L., Mascola, John R., Geleziunas, Romas, Koup, Richard A., Barouch, Dan H., Michael, Nelson L., Vasan, Sandhya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7924766/
https://ncbi.nlm.nih.gov/pubmed/33600506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009339
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