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Membrane binding and homodimerization of Atg16 via two distinct protein regions is essential for autophagy in yeast

Macroautophagy is a bulk degradation mechanism in eukaryotic cells. Efficiency of an essential step of this process in yeast, Atg8 lipidation, relies on the presence of Atg16, a subunit of the Atg12–Atg5-Atg16 complex acting as the E3-like enzyme in the ubiquitination-like reaction. A current view o...

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Bibliografiska uppgifter
I publikationen:J Mol Biol
Huvudupphovsmän: Popelka, Hana, Reinhart, Erin F., Metur, Shree Padma, Leary, Kelsie A., Ragusa, Michael J., Klionsky, Daniel J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7924733/
https://ncbi.nlm.nih.gov/pubmed/33484718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166809
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