mTORC1 activity is supported by spatial association with focal adhesions

The mammalian target of rapamycin complex 1 (mTORC1) integrates mitogenic and stress signals to control growth and metabolism. Activation of mTORC1 by amino acids and growth factors involves recruitment of the complex to the lysosomal membrane and is further supported by lysosome distribution to the...

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Published in:J Cell Biol
Main Authors: Rabanal-Ruiz, Yoana, Byron, Adam, Wirth, Alexander, Madsen, Ralitsa, Sedlackova, Lucia, Hewitt, Graeme, Nelson, Glyn, Stingele, Julian, Wills, Jimi C., Zhang, Tong, Zeug, André, Fässler, Reinhard, Vanhaesebroeck, Bart, Maddocks, Oliver D.K., Ponimaskin, Evgeni, Carroll, Bernadette, Korolchuk, Viktor I.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923692/
https://ncbi.nlm.nih.gov/pubmed/33635313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202004010
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