GFRAL-expressing neurons suppress food intake via aversive pathways

The TGFβ cytokine family member, GDF-15, reduces food intake and body weight and represents a potential treatment for obesity. Because the brainstem-restricted expression pattern of its receptor, GDNF Family Receptor α–like (GFRAL), presents an exciting opportunity to understand mechanisms of action...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sabatini, Paul V., Frikke-Schmidt, Henriette, Arthurs, Joe, Gordian, Desiree, Patel, Anita, Rupp, Alan C., Adams, Jessica M., Wang, Jine, Beck Jørgensen, Sebastian, Olson, David P., Palmiter, Richard D., Myers, Martin G., Seeley, Randy J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923658/
https://ncbi.nlm.nih.gov/pubmed/33593916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021357118
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