Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice

BACKGROUND: Intracerebral hemorrhage (ICH), a devastating subtype of stroke, is associated with high mortality and morbidity. Neuroinflammation is an important factor leading to ICH-induced neurological injuries. C-C Chemokine Receptor 4 (CCR4) plays an important role in enhancing hematoma clearance...

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Udgivet i:J Neuroinflammation
Main Authors: Deng, Shuixiang, Jin, Peng, Sherchan, Prativa, Liu, Shengpeng, Cui, Yuhui, Huang, Lei, Zhang, John H., Gong, Ye, Tang, Jiping
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923481/
https://ncbi.nlm.nih.gov/pubmed/33648537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02112-3
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