Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats

Relationships between µ-opioid receptor (MOR) efficacy and effects of mitragynine and 7-hydroxymitragynine are not fully established. We assessed in vitro binding affinity and efficacy and discriminative stimulus effects together with antinociception in rats. The binding affinities of mitragynine an...

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Pubblicato in:J Pharmacol Exp Ther
Autori principali: Obeng, Samuel, Wilkerson, Jenny L., León, Francisco, Reeves, Morgan E., Restrepo, Luis F., Gamez-Jimenez, Lea R., Patel, Avi, Pennington, Anna E., Taylor, Victoria A., Ho, Nicholas P., Braun, Tobias, Fortner, John D., Crowley, Morgan L., Williamson, Morgan R., Pallares, Victoria L.C., Mottinelli, Marco, Lopera-Londoño, Carolina, McCurdy, Christopher R., McMahon, Lance R., Hiranita, Takato
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2021
Soggetti:
Behavioral Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923387/
https://ncbi.nlm.nih.gov/pubmed/33384303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000189
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