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Targeting FBXO44/SUV39H1 elicits tumor cell-specific DNA replication stress and viral mimicry

Repetitive elements (REs) are normally transcriptionally silenced in somatic cells by repressive epigenetic modifications, which are thought to include DNA methylation and histone modifications such as deacetylation, H3K9me3, and H4K20me3. Although, it is unclear how RE silencing is maintained throu...

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Vydáno v:Cell Stress
Hlavní autoři: Shen, Jia Z., Spruck, Charles
Médium: Artigo
Jazyk:Inglês
Vydáno: Shared Science Publishers OG 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921849/
https://ncbi.nlm.nih.gov/pubmed/33681705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/cst2021.03.245
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