Inhibition of SUV39H1 Methyltransferase Activity by DBC1

SUV39H1 is a histone H3K9-specific methyltransferase important for heterochromatin formation, regulation of gene expression, and induction of senescence in premalignant cells. SUV39H1 forms a complex with SirT1, and its activity is stimulated by SirT1 binding. Here we present evidence that the produ...

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Bibliografiska uppgifter
Huvudupphovsmän: Li, Zhenyu, Chen, Lihong, Kabra, Neha, Wang, Chuangui, Fang, Jia, Chen, Jiandong
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2009
Ämnen:
Transcription, Chromatin, and Epigenetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667723/
https://ncbi.nlm.nih.gov/pubmed/19218236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900956200
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