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Inhibition of SUV39H1 Methyltransferase Activity by DBC1
SUV39H1 is a histone H3K9-specific methyltransferase important for heterochromatin formation, regulation of gene expression, and induction of senescence in premalignant cells. SUV39H1 forms a complex with SirT1, and its activity is stimulated by SirT1 binding. Here we present evidence that the produ...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2667723/ https://ncbi.nlm.nih.gov/pubmed/19218236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900956200 |
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