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A versatile, compartmentalised gut-on-a-chip system for pharmacological and toxicological analyses

A novel, integrated, in vitro gastrointestinal (GI) system is presented to study oral bioavailability parameters of small molecules. Three compartments were combined into one hyphenated, flow-through set-up. In the first compartment, a compound was exposed dynamically to enzymatic digestion in three...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: de Haan, Pim, Santbergen, Milou J. C., van der Zande, Meike, Bouwmeester, Hans, Nielen, Michel W. F., Verpoorte, Elisabeth
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921645/
https://ncbi.nlm.nih.gov/pubmed/33649376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84187-9
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