Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response

Perturbation of mitochondrial proteostasis provokes cell autonomous and cell non-autonomous responses that contribute to homeostatic adaptation. Here, we demonstrate distinct metabolic effects of hepatic metabokines as cell non-autonomous factors in mice with mitochondrial OxPhos dysfunction. Liver-...

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Pubblicato in:iScience
Autori principali: Kang, Seul Gi, Choi, Min Jeong, Jung, Saet-Byel, Chung, Hyo Kyun, Chang, Joon Young, Kim, Jung Tae, Kang, Yea Eun, Lee, Ju Hee, Hong, Hyun Jung, Jun, Sang Mi, Ro, Hyun-Joo, Suh, Jae Myoung, Kim, Hail, Auwerx, Johan, Yi, Hyon-Seung, Shong, Minho
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7920832/
https://ncbi.nlm.nih.gov/pubmed/33718833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102181
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