Reduced oxidative capacity in macrophages results in systemic insulin resistance

Oxidative functions of adipose tissue macrophages control the polarization of M1-like and M2-like phenotypes, but whether reduced macrophage oxidative function causes systemic insulin resistance in vivo is not clear. Here, we show that mice with reduced mitochondrial oxidative phosphorylation (OxPho...

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Udgivet i:Nat Commun
Main Authors: Jung, Saet-Byel, Choi, Min Jeong, Ryu, Dongryeol, Yi, Hyon-Seung, Lee, Seong Eun, Chang, Joon Young, Chung, Hyo Kyun, Kim, Yong Kyung, Kang, Seul Gi, Lee, Ju Hee, Kim, Koon Soon, Kim, Hyun Jin, Kim, Cuk-Seong, Lee, Chul-Ho, Williams, Robert W., Kim, Hail, Lee, Heung Kyu, Auwerx, Johan, Shong, Minho
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908799/
https://ncbi.nlm.nih.gov/pubmed/29674655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03998-z
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