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Conformational states dynamically populated by a kinase determine its function
Protein kinases intrinsically sample a number of conformational states with distinct catalytic and binding activities. We used nuclear magnetic resonance spectroscopy to describe in atomic-level detail how Abl kinase interconverts between an active and two discrete inactive structures. Extensive dif...
Shranjeno v:
| izdano v: | Science |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7920495/ https://ncbi.nlm.nih.gov/pubmed/33004676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc2754 |
| Oznake: |
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