Biased Effect of Cardiotonic Steroids on Na/K-ATPase–Mediated Signal Transduction

Recent studies have revealed that Na/K-ATPase (NKA) can transmit signals through ion-pumping–independent activation of pathways relayed by distinct intracellular protein/lipid kinases, and endocytosis challenges the traditional definition that cardiotonic steroids (CTS) are NKA inhibitors. Although...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Xu, Yunhui, Marck, Pauline, Huang, Minqi, Xie, Jeffrey X., Wang, Tong, Shapiro, Joseph I., Cai, Liquan, Feng, Feng, Xie, Zijian
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2021
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919863/
https://ncbi.nlm.nih.gov/pubmed/33495275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/molpharm.120.000101
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