Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy

Primary membranous nephropathy (pMN) is a leading cause of nephrotic syndrome in adults. In most cases, this autoimmune kidney disease is associated with autoantibodies against the M-type phospholipase A2 receptor (PLA2R1) expressed on kidney podocytes, but the mechanisms leading to glomerular damag...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Haddad, George, Lorenzen, Johan M., Ma, Hong, de Haan, Noortje, Seeger, Harald, Zaghrini, Christelle, Brandt, Simone, Kölling, Malte, Wegmann, Urs, Kiss, Bence, Pál, Gábor, Gál, Péter, Wüthrich, Rudolf P., Wuhrer, Manfred, Beck, Laurence H., Salant, David J., Lambeau, Gérard, Kistler, Andreas D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919733/
https://ncbi.nlm.nih.gov/pubmed/33351779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140453
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