Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p

BACKGROUND: Renal ischemia-reperfusion (I/R) injury is a major cause of AKI. Noncoding RNAs are intricately involved in the pathophysiology of this form of AKI. Transcription of hypoxia-induced, long noncoding RNA H19, which shows high embryonic expression and is silenced in adults, is upregulated i...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Haddad, George, Kölling, Malte, Wegmann, Urs A., Dettling, Angela, Seeger, Harald, Schmitt, Roland, Soerensen-Zender, Inga, Haller, Hermann, Kistler, Andreas D., Dueck, Anne, Engelhardt, Stefan, Thum, Thomas, Mueller, Thomas F., Wüthrich, Rudolf P., Lorenzen, Johan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2021
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054899/
https://ncbi.nlm.nih.gov/pubmed/33478972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020060775
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