Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy

Primary membranous nephropathy (pMN) is a leading cause of nephrotic syndrome in adults. In most cases, this autoimmune kidney disease is associated with autoantibodies against the M-type phospholipase A2 receptor (PLA2R1) expressed on kidney podocytes, but the mechanisms leading to glomerular damag...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Haddad, George, Lorenzen, Johan M., Ma, Hong, de Haan, Noortje, Seeger, Harald, Zaghrini, Christelle, Brandt, Simone, Kölling, Malte, Wegmann, Urs, Kiss, Bence, Pál, Gábor, Gál, Péter, Wüthrich, Rudolf P., Wuhrer, Manfred, Beck, Laurence H., Salant, David J., Lambeau, Gérard, Kistler, Andreas D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919733/
https://ncbi.nlm.nih.gov/pubmed/33351779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140453
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