N-Phenyl Cinnamamide Derivatives Protect Hepatocytes against Oxidative Stress by Inducing Cellular Glutathione Synthesis via Nuclear Factor (Erythroid-Derived 2)-Like 2 Activation

Substituted N-phenyl cinnamamide derivatives were designed and synthesized to confirm activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway by the electronic effect on beta-position of Michael acceptor according to introducing the R(1) and R(2) group. Compounds were screened using...

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Bibliographic Details
Published in:Molecules
Main Authors: Kim, Sou Hyun, Kim, Minwoo, Kwon, Doyoung, Pyo, Jae Sung, Kim, Joo Hyun, Kwak, Jae-Hwan, Jung, Young-Suk
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919495/
https://ncbi.nlm.nih.gov/pubmed/33672046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26041027
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