Apigenin Attenuates Acetaminophen-Induced Hepatotoxicity by Activating AMP-Activated Protein Kinase/Carnitine Palmitoyltransferase I Pathway

Overuse of acetaminophen (APAP) is a major cause of drug-induced liver failure at the clinics. Apigenin (API) is a natural flavonoid derived from Matricaria chamomilla. The aim of the present study was to investigate the amelioration function of API in APAP-induced hepatotoxicity both in vitro and i...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Zhang, Jiaqi, Liang, Xiaoqiang, Li, Jiacheng, Yin, Hao, Liu, Fangchen, Hu, Cheng, Li, Ling
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919381/
https://ncbi.nlm.nih.gov/pubmed/33658919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.549057
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