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The Effect of Octapeptide Repeats on Prion Folding and Misfolding
Misfolding of prion protein (PrP) into amyloid aggregates is the central feature of prion diseases. PrP has an amyloidogenic C-terminal domain with three α-helices and a flexible tail in the N-terminal domain in which multiple octapeptide repeats are present in most mammals. The role of the octapept...
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| Publicado no: | Int J Mol Sci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7918816/ https://ncbi.nlm.nih.gov/pubmed/33670336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22041800 |
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