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Octapeptide repeat insertions increase the rate of protease-resistant prion protein formation

A central feature of transmissible spongiform encephalopathies (TSE or prion diseases) involves the conversion of a normal, protease-sensitive glycoprotein termed prion protein (PrP-sen) into a pro-tease-resistant form, termed PrP-res. The N terminus of PrP-sen has five copies of a repeating eight a...

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Detalhes bibliográficos
Main Authors: Moore, Roger A., Herzog, Christian, Errett, John, Kocisko, David A., Arnold, Kevin M., Hayes, Stanley F., Priola, Suzette A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2249780/
https://ncbi.nlm.nih.gov/pubmed/16452616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051822606
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