The BET Inhibitor OTX015 Exhibits In Vitro and In Vivo Antitumor Activity in Pediatric Ependymoma Stem Cell Models

Childhood ependymomas are heterogenous chemoresistant neoplasms arising from aberrant stem-like cells. Epigenome deregulation plays a pivotal role in ependymoma pathogenesis, suggesting that epigenetic modifiers hold therapeutic promise against this disease. Bromodomain and extraterminal domain (BET...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Servidei, Tiziana, Meco, Daniela, Martini, Maurizio, Battaglia, Alessandra, Granitto, Alessia, Buzzonetti, Alexia, Babini, Gabriele, Massimi, Luca, Tamburrini, Gianpiero, Scambia, Giovanni, Ruggiero, Antonio, Riccardi, Riccardo
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7918371/
https://ncbi.nlm.nih.gov/pubmed/33668642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22041877
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