BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells

The bromodomain (BRD) and extraterminal (BET) proteins including BRD2, BRD3 and BRD4 have been identified as key targets for leukemia maintenance. A novel oral inhibitor of BRD2/3/4, the thienotriazolodiazepine compound OTX015, suitable for human use, is available. Here we report its biological effe...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Coudé, Marie-Magdelaine, Braun, Thorsten, Berrou, Jeannig, Dupont, Mélanie, Bertrand, Sibyl, Masse, Aline, Raffoux, Emmanuel, Itzykson, Raphaël, Delord, Marc, Riveiro, Maria E., Herait, Patrice, Baruchel, André, Dombret, Hervé, Gardin, Claude
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627339/
https://ncbi.nlm.nih.gov/pubmed/25989842
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