A carregar...
P08.63 Dose optimization of MK-8628 (OTX015), a small molecule inhibitor of bromodomain and extra-terminal (BET) proteins, in patients with recurrent glioblastoma
BACKGROUND: Bromodomains (BRD) bind to acetylated lysine residues on histone tails and are directly involved in remodeling chromatin and regulating transcription thus representing a potentially important anticancer target. MK-8628 is a synthetic small molecule targeting BRD2, 3 and 4 of the tandem-B...
Na minha lista:
| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5782691/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now188.196 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|