Enriching leukapheresis improves T cell activation and transduction efficiency during CAR T processing

The majority of CD19-directed CAR T cell products are manufactured using an autologous process. Although using a patient's leukapheresis reduces the risks of rejection, it introduces variability in starting material composition and the presence of cell populations that might negatively affect p...

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Bibliografiske detaljer
Udgivet i:Mol Ther Methods Clin Dev
Main Authors: Noaks, Elsa, Peticone, Carlotta, Kotsopoulou, Ekaterini, Bracewell, Daniel G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2021
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917474/
https://ncbi.nlm.nih.gov/pubmed/33718517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.02.002
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