Single-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signatures

Chimeric antigen receptor (CAR) T-cell adoptive therapy is set to transform the treatment of a rapidly expanding range of malignancies. Although the activation process of normal T cells is well characterized, comparatively little is known about the activation of cells via the CAR. Here we have used...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Wang, Xiaonan, Peticone, Carlotta, Kotsopoulou, Ekaterini, Göttgens, Berthold, Calero-Nieto, Fernando J
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2021
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801130/
https://ncbi.nlm.nih.gov/pubmed/33489472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1866287
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