Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells

Whereas hundreds of cells in the mouse embryonic aorta transdifferentiate to hematopoietic cells, only very few establish hematopoietic stem cell (HSC) identity at a single time point. The Gata2 transcription factor is essential for HSC generation and function. In contrast to surface-marker-based ce...

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Vydáno v:Cell Rep
Hlavní autoři: Vink, Chris Sebastiaan, Calero-Nieto, Fernando Jose, Wang, Xiaonan, Maglitto, Antonio, Mariani, Samanta Antonella, Jawaid, Wajid, Göttgens, Berthold, Dzierzak, Elaine
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225750/
https://ncbi.nlm.nih.gov/pubmed/32402290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107627
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