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Enriching leukapheresis improves T cell activation and transduction efficiency during CAR T processing
The majority of CD19-directed CAR T cell products are manufactured using an autologous process. Although using a patient's leukapheresis reduces the risks of rejection, it introduces variability in starting material composition and the presence of cell populations that might negatively affect p...
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| Publicado no: | Mol Ther Methods Clin Dev |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Gene & Cell Therapy
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7917474/ https://ncbi.nlm.nih.gov/pubmed/33718517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.02.002 |
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