OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance

OTS964 is a potent T-LAK cell-originated protein kinase (TOPK) inhibitor. Herein, we investigated the interaction of OTS964 and multidrug resistance (MDR)-associated ATP-binding cassette sub-family G member 2 (ABCG2). The cell viability assay indicated that the effect of OTS964 is limited in cancer...

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書目詳細資料
發表在:Front Pharmacol
Main Authors: Yang, Yuqi, Wu, Zhuo-Xun, Wang, Jing-Quan, Teng, Qiu-Xu, Lei, Zi-Ning, Lusvarghi, Sabrina, Ambudkar, Suresh V., Chen, Zhe-Sheng, Yang, Dong-Hua
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2021
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917255/
https://ncbi.nlm.nih.gov/pubmed/33658942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.620874
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