Genetic Perturbation of Pyruvate Dehydrogenase Kinase 1 Modulates Growth, Angiogenesis and Metabolic Pathways in Ovarian Cancer Xenografts

Pyruvate dehydrogenase kinase 1 (PDK1) blockade triggers are well characterized in vitro metabolic alterations in cancer cells, including reduced glycolysis and increased glucose oxidation. Here, by gene expression profiling and digital pathology-mediated quantification of in situ markers in tumors,...

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Publicado no:Cells
Main Authors: Venturoli, Carolina, Piga, Ilaria, Curtarello, Matteo, Verza, Martina, Esposito, Giovanni, Venuto, Santina, Navaglia, Filippo, Grassi, Angela, Indraccolo, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7915933/
https://ncbi.nlm.nih.gov/pubmed/33562444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10020325
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