Genetic perturbation of IFN-α transcriptional modulators in human endothelial cells uncovers pivotal regulators of angiogenesis

Interferon-α (IFN-α) comprises a family of 13 cytokines involved in the modulation of antiviral, immune, and anticancer responses by orchestrating a complex transcriptional network. The activation of IFN-α signaling pathway in endothelial cells results in decreased proliferation and migration, ultim...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Ciccarese, Francesco, Grassi, Angela, Pasqualini, Lorenza, Rosano, Stefania, Noghero, Alessio, Montenegro, Francesca, Bussolino, Federico, Di Camillo, Barbara, Finesso, Lorenzo, Toffolo, Gianna Maria, Mitola, Stefania, Indraccolo, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734228/
https://ncbi.nlm.nih.gov/pubmed/33335694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.11.048
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