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Differential Regulation of Bilastine Affinity for Human Histamine H(1) Receptors by Lys 179 and Lys 191 via Its Binding Enthalpy and Entropy
Bilastine, a zwitterionic second-generation antihistamine containing a carboxyl group, has higher selectivity for H(1) receptors than first-generation antihistamines. Ligand-receptor docking simulations have suggested that the electrostatic interaction between the carboxyl group of second-generation...
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| Publicado no: | Int J Mol Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7915449/ https://ncbi.nlm.nih.gov/pubmed/33562121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22041655 |
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