Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H(1) Receptors

Cetirizine is a zwitterionic second-generation antihistamine containing R- and S-enantiomers, levocetirizine, and (S)-cetirizine. Levocetirizine is known to have a higher affinity for the histamine H(1) receptors than (S)-cetirizine; ligand-receptor docking simulations have suggested the importance...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Hishinuma, Shigeru, Tamura, Yuri, Kobayashi, Chihiro, Akatsu, Chizuru, Shoji, Masaru
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
Témata:
Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6321019/
https://ncbi.nlm.nih.gov/pubmed/30558340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19124067
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