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Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors

Largely non-overlapping sets of cyclin-dependent kinases (CDKs) regulate cell division and RNA polymerase II (Pol II)-dependent transcription. Here we review the molecular mechanisms by which specific CDKs are thought to act at discrete steps in the transcription cycle and describe the recent emerge...

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Publicat a:Nat Chem Biol
Autors principals: Parua, Pabitra K., Fisher, Robert P.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7914107/
https://ncbi.nlm.nih.gov/pubmed/32572259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0563-4
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