The nascent polypeptide in the 60S subunit determines the Rqc2-dependency of ribosomal quality control

Ribosome stalling at tandem CGA codons or poly(A) sequences activates quality controls for nascent polypeptides including ribosome-associated quality control (RQC) and no-go mRNA decay (NGD). In RQC pathway, Hel2-dependent uS10 ubiquitination and the RQC-trigger (RQT) complex are essential for subun...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Mizuno, Masato, Ebine, Shuhei, Shounai, Okuto, Nakajima, Shizuka, Tomomatsu, Shota, Ikeuchi, Ken, Matsuo, Yoshitaka, Inada, Toshifumi
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913769/
https://ncbi.nlm.nih.gov/pubmed/33511411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab005
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