SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites

Glucocorticoid receptor (GR) is an essential transcription factor (TF), controlling metabolism, development and immune responses. SUMOylation regulates chromatin occupancy and target gene expression of GR in a locus-selective manner, but the mechanism of regulation has remained elusive. Here, we ide...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Paakinaho, Ville, Lempiäinen, Joanna K, Sigismondo, Gianluca, Niskanen, Einari A, Malinen, Marjo, Jääskeläinen, Tiina, Varjosalo, Markku, Krijgsveld, Jeroen, Palvimo, Jorma J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2021
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913686/
https://ncbi.nlm.nih.gov/pubmed/33524141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab032
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