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Property-Unmatched Decoys in Docking Benchmarks

Enrichment of ligands versus property-matched decoys is widely used to test and optimize docking library screens. However, the unconstrained optimization of enrichment alone can mislead, leading to false confidence in prospective performance. This can arise by over-optimizing for enrichment against...

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Detalles Bibliográficos
Publicado en:J Chem Inf Model
Autores principales: Stein, Reed M., Yang, Ying, Balius, Trent E., O’Meara, Matt J., Lyu, Jiankun, Young, Jennifer, Tang, Khanh, Shoichet, Brian K., Irwin, John J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913603/
https://ncbi.nlm.nih.gov/pubmed/33494610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.0c00598
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