The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis

Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for maintaining and enhancing HIF-1α-mediated transactivation and glycolysis. Mechanistically, HIFAL recruits prolyl hydroxylase 3 (P...

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Vydáno v:Nat Commun
Hlavní autoři: Zheng, Fang, Chen, Jianing, Zhang, Xiaoqian, Wang, Zifeng, Chen, Jiewen, Lin, Xiaorong, Huang, Hongyan, Fu, Wenkui, Liang, Jing, Wu, Wei, Li, Bo, Yao, Herui, Hu, Hai, Song, Erwei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910558/
https://ncbi.nlm.nih.gov/pubmed/33637716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21535-3
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