Transglutaminase 2: a novel therapeutic target for idiopathic pulmonary fibrosis using selective small molecule inhibitors

This study investigates the effects of a site-directed TG2-selective inhibitor on the lung myofibroblast phenotype and ECM deposition to elucidate TG2 as a novel therapeutic target in idiopathic pulmonary fibrosis (IPF)—an incurable progressive fibrotic disease. IPF fibroblasts showed increased expr...

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Опубликовано в: :Amino Acids
Главные авторы: Fell, Shaun, Wang, Zhuo, Blanchard, Andy, Nanthakumar, Carmel, Griffin, Martin
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Vienna 2021
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910249/
https://ncbi.nlm.nih.gov/pubmed/33474654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-020-02938-w
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