A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition

UTX/KDM6A encodes a major histone H3 lysine 27 (H3K27) demethylase, and is frequently mutated in various types of human cancers. Although UTX appears to play a crucial role in oncogenesis, the mechanisms involved are still largely unknown. Here we show that a specific pharmacological inhibitor of H3...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Kitajima, Shojiro, Sun, Wendi, Lee, Kian Leong, Ho, Jolene Caifeng, Oyadomari, Seiichi, Okamoto, Takashi, Masai, Hisao, Poellinger, Lorenz, Kato, Hiroyuki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907191/
https://ncbi.nlm.nih.gov/pubmed/33633164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83857-y
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