The Hypoxia-Inducible Epigenetic Regulators Jmjd1a and G9a Provide a Mechanistic Link between Angiogenesis and Tumor Growth

Hypoxia promotes stem cell maintenance and tumor progression, but it remains unclear how it regulates long-term adaptation toward these processes. We reveal a striking downregulation of the hypoxia-inducible histone H3 lysine 9 (H3K9) demethylase JMJD1A as a hallmark of clinical human germ cell-deri...

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Hauptverfasser: Ueda, Jun, Ho, Jolene Caifeng, Lee, Kian Leong, Kitajima, Shojiro, Yang, Henry, Sun, Wendi, Fukuhara, Noriko, Zaiden, Norazean, Chan, Shing Leng, Tachibana, Makoto, Shinkai, Yoichi, Kato, Hiroyuki, Poellinger, Lorenz
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187738/
https://ncbi.nlm.nih.gov/pubmed/25071150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00099-14
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