Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer

The advanced or recurrent endometrial cancer (EC) has a poor prognosis because of chemoresistance. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a glycolytic enzyme, is overexpressed in a variety of human cancers and plays important roles in promoting tumor cell growth. Here, we s...

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Publicat a:Oncogene
Autors principals: Xiao, Yinan, Jin, Ling, Deng, Chaolin, Guan, Ye, Kalogera, Eleftheria, Ray, Upasana, Thirusangu, Prabhu, Staub, Julie, Sarkar Bhattacharya, Sayantani, Xu, Haotian, Fang, Xiaoling, Shridhar, Viji
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906909/
https://ncbi.nlm.nih.gov/pubmed/33420377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01621-4
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