PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses

The metabolic signatures of cancer cells are often associated with elevated glycolysis. Pharmacological (PFK158 treatment) and genetic inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a critical control point in the glycolytic pathway, decreases glucose uptake, ATP produ...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Sarkar Bhattacharya, Sayantani, Thirusangu, Prabhu, Jin, Ling, Roy, Debarshi, Jung, Deokbeom, Xiao, Yinan, Staub, Julie, Roy, Bhaskar, Molina, Julian R., Shridhar, Viji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764980/
https://ncbi.nlm.nih.gov/pubmed/31562297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1916-3
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados