Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines

Dysregulated iron metabolism is a hallmark of many cancers, including glioblastoma (GBM). However, its role in tumor progression remains unclear. Herein, we identified coatomer protein complex subunit zeta 1 (COPZ1) as a therapeutic target candidate which significantly dysregulated iron metabolism i...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Zhang, Yulin, Kong, Yang, Ma, Yuan, Ni, Shilei, Wikerholmen, Tobias, Xi, Kaiyan, Zhao, Feihu, Zhao, Zhimin, Wang, Junpeng, Huang, Bin, Chen, Anjing, Yao, Zhong, Han, Mingzhi, Feng, Zichao, Hu, Yaotian, Thorsen, Frits, Wang, Jian, Li, Xingang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906905/
https://ncbi.nlm.nih.gov/pubmed/33420375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01622-3
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