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In vitro evaluation of the metabolic enzymes and drug interaction potential of triapine

PURPOSE: To investigate the metabolic pathways of triapine in primary cultures of human hepatocytes and human hepatic subcellular fractions; to investigate interactions of triapine with tenofovir and emtricitabine; and to evaluate triapine as a perpetrator of drug interactions. The results will bett...

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Uloženo v:
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Vydáno v:Cancer Chemother Pharmacol
Hlavní autoři: Joshi, Anand, Kiesel, Brian F., Chaphekar, Nupur, Jones, Reyna, Guo, Jianxia, Kunos, Charles A., Taylor, Sarah, Chu, Edward, Venkataramanan, Raman, Beumer, Jan H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906094/
https://ncbi.nlm.nih.gov/pubmed/32989483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04154-5
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