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Phase I trial of daily triapine in combination with cisplatin chemotherapy for advanced-stage malignancies
PURPOSE: Advanced-stage malignancies have increased deoxyribonucleotide demands in DNA replication and repair, making deoxyribonucleotide supply a potential exploitable target for therapy based on ribonucleotide reductase (RNR) inhibition. METHODS: A dose-finding phase I trial was conducted of intra...
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| Publicado no: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5226891/ https://ncbi.nlm.nih.gov/pubmed/27878356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-3200-x |
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