Bicyclic Chalcones as Mitotic Inhibitors for Overcoming Androgen Receptor-Independent and Multidrug-Resistant Prostate Cancer

[Image: see text] To improve the biological effects of the lead compound 5′-chloro-2,2′-dihydroxychalcone (Cl-DHC), bicyclic aromatic chalcones were designed, synthesized, and evaluated against androgen-independent prostate cancer (PCa) DU145 and PC-3 cell proliferation. Newly synthesized bi-naphthy...

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Bibliographic Details
Published in:ACS Omega
Main Authors: Saito, Yohei, Mizokami, Atsushi, Maeda, Sayaka, Takahashi, Kyoko, Izumi, Kouji, Goto, Masuo, Nakagawa-Goto, Kyoko
Format: Artigo
Language:Inglês
Published: American Chemical Society 2021
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905931/
https://ncbi.nlm.nih.gov/pubmed/33644592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c05822
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