Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms

Stable atherosclerotic plaques are characterized by a thick extracellular matrix (ECM)-rich fibrous cap populated by protective ACTA2(+) myofibroblast (MF)-like cells, assumed to be almost exclusively derived from smooth muscle cells (SMC). Herein, we show that in murine and human lesions, 20 to 40%...

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Publicat a:Nat Metab
Autors principals: Newman, Alexandra AC, Serbulea, Vlad, Baylis, Richard A, Shankman, Laura S, Bradley, Xenia, Alencar, Gabriel F, Owsiany, Katherine, Deaton, Rebecca A, Karnewar, Santosh, Shamsuzzaman, Sohel, Salamon, Anita, Reddy, Mahima S, Guo, Liang, Finn, Aloke, Virmani, Renu, Cherepanova, Olga A, Owens, Gary K
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905710/
https://ncbi.nlm.nih.gov/pubmed/33619382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-00338-8
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