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Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice

Lipophilic statins which are blood brain barrier (BBB) permeable are speculated to affect the cholesterol synthesis and neural functions in the central nervous system. However, whether these statins can affect cholesterol levels and synaptic plasticity in hippocampus and the in vivo consequence rema...

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Dades bibliogràfiques
Publicat a:Mol Brain
Autors principals: Guo, Yujun, Zou, Guichang, Qi, Keke, Jin, Jin, Yao, Lei, Pan, Yang, Xiong, Wei
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905661/
https://ncbi.nlm.nih.gov/pubmed/33627175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-021-00758-x
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